In vitro fertilizasyon (IVF)

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  • ANTALYA IVF TREATMENT, 2023 PRİCES

    Antalya IVF Treatment

    If you are looking for Antalya IVF Center with a Gynecology & Obstetrics and IVF Specialist who is experienced in Antalya IVF Treatment and has achieved successful results in previous treatments, you are at the right address. By contacting us, you can get detailed information about Antalya IVF Treatment and Antalya IVF Treatment Prices and make it easier for you to make a decision about the IVF process.

    Antalya IVF is the fertilization process of male and female reproductive cells outside the body. For the first time in 1978, a baby named Louise Brown was born in England by in vitro fertilization method. In Turkey, as in the rest of the world, developments regarding in vitro fertilization continue rapidly.

    IVF treatments consist of 3 basic stages. The first step begins with stimulating the ovaries with drugs to produce large numbers of egg cells. In the second step, these eggs are collected and fertilized to form embryos in the laboratory environment. The third step is the process of transferring the fertilized embryos to the mother's womb. A pregnancy test is done 10-12 days after the transfer.

    First Interview and Inspection

    IVF Treatment is performed by Gynecologists and Obstetricians specializing in IVF in Antalya and Turkey. In the first interview, a comprehensive history is taken, previous tests are examined and examined. If the semen analysis is normal and there is no sexual dysfunction, the man does not need to be examined. In case of abnormal sperm results, the man's urological examination and advanced tests are required. The examination of the woman is of great importance in terms of determining the chance of conceiving in vitro. In the examination, the reserve (capacity) of the ovaries, the presence of cysts in the ovaries, the structure of the uterus, the presence of space-occupying formations such as fibroids, polyps, septum (curtain) are evaluated. If the PAP Smear test has not been taken before, it is recommended to be taken during the examination, and if there is vaginal discharge, a vaginal culture should be performed.

    Following the evaluation of the history, examination and tests, information is given about the stages of IVF. Treatment for each couple is individualized. Information about the planned treatment approach, the possibility of pregnancy and the side effects of the applications are also shared with the couples.

    ANTALYA IVF DOCTOR

    PREPARATİON FOR ANTALYA IVF TREATMENT

    Things to do in preparation for treatment:

    If smoking should be stopped. Alcohol use should be avoided.

    Weight control should be ensured. Being overweight or underweight can reduce pregnancy success.

    A multivitamin containing folic acid and, if necessary, antioxidant products should be started.

    Effective communication can reduce stress and anxiety, and professional support should be sought when necessary.

    Pay attention to the sleeping pattern.

    The benefits of a protein-rich diet can be said.

    Laboratory tests should be completed before treatment. (such as hormones, Hepatitis B and C screening, HIV, Rubella IgG, blood count, ferritin, blood group determination, vitamin D, blood sugar)

    STİMULATİON OF THE OVARİES

    The average duration of treatment is 10-11 days. On the second or third day of menstrual bleeding, ultrasound examination and determination of estrogen in the blood are performed. The dose of the drug to be used is decided. On certain days of the treatment, the patient is called for control at certain intervals. In these controls, the number and size of the developing follicles (water-filled sacs in which the eggs are contained) are checked by performing vaginal ultrasonography. From time to time, depending on the condition of the ovaries, a blood estrogen analysis may be required.

    The aim of treatment is to obtain as many follicles with a diameter of 16-20 mm as possible. When the follicles reach a sufficient size, hcg and or GNRHa injection (cracking needle) is performed to ensure the maturation of the eggs. Egg collection is done 34-36 hours after the cracking needle.

    EGG COLLECTİON PROCESS

    Egg collection process (oocyte pickup-OPU) is the discharge of fluid-filled structures called follicles containing eggs by entering the ovary with a needle under the guidance of vaginal ultrasound. The egg is a small cell that can only be seen under a microscope. The OPU procedure is mostly performed with general anesthesia. However, it can also be performed under local anesthesia when necessary. The process takes about 10-15 minutes. Unfortunately, not every follicle produces an egg. In general, 70% of the follicles contain eggs. A few hours after the eggs are collected, they are evaluated whether they are mature or not. The mature eggs are fertilized with the classical ivf or icsi method. After resting for 2 hours after egg collection, the patient is sent home.

    INFORMATİON BEFORE EGG COLLECTİON

    Please make your injections on the day and time you are told.

    You should not eat or drink anything (this includes a small amount of water, chewing gum and cigarettes) after 24.00 the night before the operation.

    Please be at our clinic 30 minutes before the appointment time.

    Do not drive as you will receive anesthesia on the day of the operation.

    You must have an adult with you on the day of the procedure.

    Do not take valuables with you. Remove rings, necklaces, etc., and deliver your valuables such as credit cards and money to a relative.

    Please come home with a shower.

    Attention!

    The dosage and timing of the drug to be applied for the final maturation of the eggs is very important. A mistake that can be made may cause no eggs to be obtained in the egg collection process.

    ANESTHESİA INFORMATİON

    Operation Day

    • Do not eat, drink or smoke anything from 6 hours before the operation.
    • If you have a drug that you use constantly, use it as the anesthesiologist tells you.
    • If you have a febrile illness, be sure to tell the anesthesiologist.
    • Just Before the Operation
    • Go to the toilet and empty your bladder
    • If you have a denture, remove it
    • If you have a lens, remove it.
    • Remove your watches and jewelry
    • Remove your makeup and nail polish
    • In the Operations Room

    A catheter will be placed in your vein and any medicine will be given in this way.

    A special device will monitor your heart and lung functions throughout the operation.

    • Post-Operation
    • You will rest until you come to your senses. You can leave the clinic after you are given the necessary information about what to do after the procedure.
    • 12 hours after the operation
    • Do not drive!
    • Avoid activities that require attention!
    • At home

    After the egg retrieval procedure, you may have pain in your groin and a small amount of vaginal bleeding.

    After the egg collection process, spend the day resting, do not do heavy and tiring work.

    If you have pain, you can use paracetamol derivative pain relievers.

    Call your doctor if you have extreme pain, fever, nausea, vomiting

    You can take a shower whenever you want.

    Even if you don't need a special diet, try to drink plenty of fluids.

    Do not use alcohol.

    The next day of egg collection (Monday, if collected on Saturday) until 16.00, a person in charge of the Embryology laboratory will call you and let you know how many eggs have been fertilized.

    In case of constant and severe groin pain, nausea, vomiting and excessive amount of vaginal bleeding, call us immediately.

    SPERM

    There is no harm in continuing your normal sexual life until the egg cracking injection is made. However, sexual intercourse is not recommended until the egg collection process after the cracking injection is made. In addition, a period of abstinence longer than one week is not preferred, long abstinence has a negative effect on sperm quality.

    During the egg collection process, sperm are also taken from the male. Sperm sample should be given in our rooms specially prepared for this job. The sperm is taken by masturbation and into a sterile container. Substances such as soap, saliva, etc. should not be used. For example, it is not recommended to bring it from home, except in special circumstances. Our patients who have difficulties in giving samples should notify this situation to your nurse or laboratory staff in advance.

    Sperm preparation

    The sperm sample taken is subjected to some processes and the motile and normal sperm are separated. In the classical IVF method, 25000 – 75000 sperm are left around each egg and one of them is expected to fertilize the egg.

    In the microinjection (ICSI) procedure, a sperm is injected into each egg under the microscope.

    FERTİLİZATİON – IVF VS ICSI

    Fertilization takes place by classical in vitro fertilization or microinjection method. Fertilization takes place approximately 2-4 hours after the eggs are collected.

    In classical in vitro fertilization, the sperms are left next to the collected eggs and they are expected to fertilize the egg spontaneously. It is used in cases where the man's sperm is normal.

    In microinjection, a single sperm is injected into the egg with the help of a special tool called a micromanipulator. It is used in patients with insufficient sperm values ​​and recurrent IVF failures.

    Fertilization occurs in about 12-15 hours and is detected under the microscope. Fertilized eggs are tracked until the time to be transferred. In some cases, eggs may not be fertilized or healthy embryos may not develop. In this case, the transfer process will be cancelled. The fertilization rates of the eggs and the quality and number of developing embryos will be shared with you by our embryologists. Approximately 70% of the collected eggs are mature and suitable for fertilization. About 70% of them will also be fertilized.

    EMBRYO TRANSFER

    The most preferred transfer times are day 3 (4-8 cells) and day 5 (blastocyst). There is a direct relationship between the number of embryos transferred and clinical pregnancy rates. The best clinical results are obtained with the transfer of 2 embryos. Single egg transfer is preferred because of the high complication rates of multiple pregnancies. The number of embryos that can be transferred is specified in the IVF regulation of 2010 according to the age of the woman, and these rules are not violated in our clinic. Two embryo transfers are performed in patients older than 35 years of age or in patients who have failed previous IVF/ICSI attempts. One blastocyst transfer is recommended in patients younger than 35 years of age. If a large number of embryos of good quality have been obtained, the remaining embryos can be frozen with your permission.

    Embryos formed are gently passed through the cervix with the help of a thin plastic catheter and given into the uterus. Embryo transfer is not a painful procedure, it is very simple and does not require anesthesia. It is recommended that your bladder be full so that you can see the area where the embryos to be placed in the uterus will be left during the transfer, on ultrasound. For this reason, it is recommended that you come to the transfer with congested urine. After the embryos are placed in the uterus, it is sufficient to rest for a short time. There is no need to limit activity after leaving the hospital. Exercising and sexual intercourse are not recommended. After the procedure, the patient is given hormone drugs in the form of injections, suppositories or creams to support the endometrium. This treatment is 10-12 days if pregnancy occurs. continues for a week.

    On the 12th day after embryo transfer, the patient is called for a pregnancy test.

    PREGNANCY TEST AFTER IVF TREATMENT

    On the 12th day after the transfer, a blood pregnancy test (beta-hCG) is performed. Those who test positive are called for a blood pregnancy test again two days later. In a healthy pregnancy, the blood beta-hCG value should increase approximately twice after two days. In the presence of b-hcg values ​​that do not increase regularly, they are followed by serial b-hcg tests. After 1 week, she is called for the first pregnancy ultrasound. In this first ultrasound examination, the presence of a gestational sac in the uterus and whether there is a multiple pregnancy can be seen.

    Bleeding does not mean that the patient is not pregnant. Definitive diagnosis is made with a blood pregnancy test. In cases of biochemical or ectopic pregnancy, no gestational sac is seen in the uterus. The distinction is made by serial b-hcg and ultrasonography follow-ups.

    IF THE PREGNANCY TEST İS NEGATİVE:

    The result of your pregnancy test will be notified to you by your doctor or our IVF nurses. Although it is sad that the test is negative, it is not the end of the world. Do not forget that pregnancy rates per trial in IVF applications do not exceed 50% even under the best conditions all over the world. When you get a negative result, make an appointment and talk to your doctor. Having this meeting between two patients or on their feet will not satisfy neither you nor your doctor. In the interview, you will be told when the next treatment will be started and what needs to be done beforehand.

    WHAT TO DO AFTER EMBRYO TRANSFER

    Should I lie down for a certain period of time after embryo transfer? In the years when in vitro fertilization treatments were first implemented, the standard practice was to give long-term bed rest to patients after embryo transfer in order to prevent the embryo from falling before it could adhere to the inner layer of the uterus. However, studies conducted in recent years have concluded that bed rest does not provide any benefit. It is actually quite reasonable that bed rest given after embryo transfer does not increase pregnancy rates. First, the endometrial cavity (intrauterine cavity) is not actually a cavity, but rather an area with the potential to open. During embryo transfer, the opposing walls of the endometrium separate momentarily, but rejoin immediately when the catheter is withdrawn. Therefore, it is unlikely that the embryo will fall out of the cavity when the patient stands up. Second, when the air bubbles formed by the embryo as a result of embryo transfer were observed on ultrasound, it was seen that gravity or standing up did not have a significant effect on the position of the embryo. Short-term bed rest is not necessary as it provides no benefit. Prolonged bed rest is also not recommended as it does not increase pregnancy rates.

    Can we have sexual intercourse after embryo transfer? Women undergoing IVF treatment are concerned that having sexual intercourse, especially orgasm, after embryo transfer will prevent the embryo from attaching. The results of two studies on patients who had and did not have sexual intercourse after transfer showed that sexual activity did not have a negative effect on the success of IVF treatment. It has been suggested that having sexual intercourse after embryo transfer may pose two risks for the woman undergoing IVF treatment. First, a woman's ovaries, which contain more than one corpus luteum and are enlarged due to hyperstimulation syndrome (overstimulation), may be at risk of rupture during sexual intercourse, which can cause pain and even significant intra-abdominal bleeding. Therefore, sexual intercourse should be avoided in patients with ovarian hyperstimulation syndrome (overstimulation) during treatment. As a result, when we look at the evidence we have, couples can have sexual intercourse after embryo transfer, except in cases where the woman experiences pain and discomfort in the groin due to overstimulation of the ovaries. However, more data is needed on this subject. Today, most IVF centers do not recommend post-transfer sexual intercourse. Therefore, sexual intercourse should be avoided in patients with ovarian hyperstimulation syndrome (overstimulation) during treatment. As a result, when we look at the evidence we have, couples can have sexual intercourse after embryo transfer, except in cases where the woman experiences pain and discomfort in the groin due to overstimulation of the ovaries. However, more data is needed on this subject. Today, most IVF centers do not recommend post-transfer sexual intercourse. Therefore, sexual intercourse should be avoided in patients with ovarian hyperstimulation syndrome (overstimulation) during treatment. As a result, when we look at the evidence we have, couples can have sexual intercourse after embryo transfer, except in cases where the woman experiences pain and discomfort in the groin due to overstimulation of the ovaries. However, more data is needed on this subject. Today, most IVF centers do not recommend post-transfer sexual intercourse.

    Can I do sports after embryo transfer? Many patients worry that exercising at a fast pace after embryo transfer will prevent the embryo from attaching. It has been observed that performing more than 4 hours of fast-paced cardiovascular exercise per week reduces the implantation rate and increases the risk of miscarriage. Exercise can prevent pregnancy from occurring for several reasons. The mechanical vibrations created by the spores can dislocate the embryo trying to hold on. It is known that fast-paced exercises can raise the average body temperature up to 2 degrees. It has been reported that these increases in body temperature lead to anomalies resulting in miscarriage and death. It is safest to avoid intense cardiovascular exercise after embryo transfer and to do light exercise such as walking for up to 30 minutes a day.

    Do I have to take leave from my workplace after embryo transfer? Studies have shown that reducing the workload does not have a positive effect on IVF success. However, there is some evidence that the increase in the patient's anxiety and stress level during treatment negatively affects IVF success. Post-transfer leave may be appropriate if the work environment is very stressful or if the patient is exposed to toxins (such as chemicals, radiation) that may be harmful to reproductive health.

    ANTALYA IVF CALCULATİON

    If you got pregnant with the IVF method and are wondering how many weeks pregnant I am, first select your calculation method in our calculation tool, then enter the relevant date and press the calculate button.

    Antalya IVF Treatment Prices 2020

    Antalya IVF Treatment Prices vary according to couples. Prices vary depending on the process to be performed. The most affordable price is in egg collection, embryo creation and transfer applications. The cost will increase when procedures such as TESE, ICSI, embryo freezing, genetic examination, and embryo sheath thinning are performed. You can call our clinic for detailed information about Antalya IVF Treatment Prices. For information,   you can contact us at 0242 312 2 312 – 0546 202 87 44 .

    Communication is very important in the treatment process, as in everything else. Please contact us if you have any issues during the treatment process.

  • IVF TREATMENT PROBLEMS

    PROBLEMS ENCOUNTERED DURİNG IVF TREATMENT

    Cancellation of treatment: The treatment can be canceled due to reasons such as the patients not responding to the treatment as expected, and insufficient number of follicles to develop.

    Failure to find eggs: Although the follicles reach sufficient size, especially in women of advanced age and low ovarian reserve, no eggs may be found during egg collection.

    No sperm can be found: 40% of the patients undergoing TESE cannot find sperm and the treatment has to be cancelled.

    Lack of fertilization: Although eggs and sperm are normal, fertilization may not occur in some eggs. Fertilization rate is around 70%.

    Stopping of development in embryos: Embryos are followed daily by laboratory staff according to their development and division characteristics. In these follow-ups, the quality of the embryos is monitored. In the follow-ups, sometimes the embryos may not develop until the 3rd or 5th day.

    Difficulty in transfer: In some cases, the transfer may be very difficult due to the anatomical structure of the woman's genital organs. In such cases, the chance of pregnancy decreases.

    Bleeding before pregnancy test: Although the chance of pregnancy decreases in those who have bleeding before the test day, it does not mean that there is no pregnancy.

    OVARİAN HYPERSTİMULATİON SYNDROME (OHSS)

    OHSS is the most important complication of IVF treatment. It usually occurs in young women with polycysticovarian syndrome and good ovarian reserve. The probability of its severe form is around 5%. Excessive response to drugs used to stimulate the ovaries paves the way for the syndrome. There is a fine line between stimulating an acceptable number of eggs during ovarian stimulation and overstimulation. Dose adjustment is not always possible. When there is overstimulation, reducing the dose of ovarian stimulating drugs and not giving the drug for a day or more when necessary, prevents the excessive increase of estrogen. The syndrome does not occur in cases where the hCG injection is not given before the egg retrieval. Pregnancy causes the syndrome to develop more severely.

    Ovarian Hyperstimulation Syndrome (OHSS) Symptoms

    Increase in ovarian size

    Abdominal pain, bloating, shortness of breath, decreased urine output

    Fluid collection in the abdominal cavity

    Coagulation disorders

    Fluid collection in the chest cavity

    Prevention of the syndrome: Egg collection can be canceled and in this case, the disease does not develop. In cases where the cancellation of the egg total process is not desired:

    HCG dose can be reduced

    Special fluids may be given during egg collection. (HSA, HEPP)

    After the eggs are collected and fertilized, they can all be frozen. The emergence of the syndrome can be prevented with a probability of 80-90% with some drugs to be given at this time.

    If embryo transfer is to be done, the number should be reduced. It is preferable to transfer 1 or at most 2 embryos. The syndrome is more severe in multiple pregnancies.

    Treatment:

    In the mild form of the syndrome, hospitalization is not required. Salt and fluid restriction is recommended. Daily weight and abdominal circumference measurements are important. In case of more than 3 cm increase in abdominal circumference in one day, increase in body weight more than 2 kg in a day, decrease in urine amount, shortness of breath, the doctor should be informed.

    If the syndrome is severe, hospitalization is required. In the meantime, giving serum and draining the fluid accumulated in the abdomen with a needle (paracentesis) turns the course of the disease in a positive direction. In some cases, the hospital stay can be up to 2-3 weeks. During this period, cases requiring 10-15 paracentesis have been reported.

    The syndrome regresses in a short time in women who do not become pregnant. However, the process may be prolonged in pregnant women.

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